I think us humans are the only species on this planet which creates scenarios and imposes self-invented rules upon itself where it’s not allowed to relieve oneself for hours at a time. Granted, we’re also the only species that can comfortably take a dump while travelling at 900 km/h at 30,000 feet altitude, so I guess we’re cursed and privileged at the same time.
However, I think we all have been where Jason is in this comic. Are there any people out there who do not go quiet in a situation like this? I think that’s pretty universal.